PW03-025 - Procaspase-1 contributes to inflammation via NF-KB
نویسندگان
چکیده
Introduction Caspase-1 is a pro-inflammatory enzyme which gets activated by autoprocessing following the assembly of multiprotein complexes called inflammasomes. Mature caspase-1 is responsible for the activation of the proinflammatory cytokines interleukin (IL)-1b and IL-18. Luksch and colleagues reported naturally occurring CASP1 genetic variants in patients suffering from unexplained recurrent febrile episodes. Paradoxically, in vitro and in vivo analyses revealed decreased enzymatic activity of these caspase-1 variants leading to impaired cytokine production. A study of Lamkanfi and colleagues provides a possible explanation by indicating a link between enzymatically inactive procaspase-1 and activation of NFB, a pro-inflammatory transcription factor.
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